znt8 type 2 diabetes
Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets 1, 2, 3, but none have yet been described for type 2. Historical aspects. the identification of islet cell antibodies (ica) was a key step towards recognition of type 1 diabetes as an immune mediated disease.. Znt8 autoantibody epitope specificity and affinity examined with recombinant znt8 variant proteins in specific znt8r and znt8w autoantibody positive type 1 diabetes.
Znt8 burst onto the scene in 2007 as a promising diabetes target, and follow-up studies suggested that stimulating the zinc transporter protein could have therapeutic. Zinc transporter 8 antibodies complement gad and ia-2 antibodies in the identification and characterization of adult-onset autoimmune diabetes. 1. genet mol res. 2012 may 24;11(2):1592-8. doi: 10.4238/2012.may.24.1. slc30a8 (znt8) variations and type 2 diabetes in the chinese han population..
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